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Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information. At the end of this process the T-cell is either activated or remains inactive.
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The T-cell makes contact with the antigen-presenting cell by means of specialized adhesion molecules which initially are randomly distributed over the cell surface. The loose bond formed between the two cell surfaces allows for the binding of T-cell receptors to the presented antigen.
Where immunological synapses are correctly formed, the receptor molecules are concentrated around a central point whereas the other surface proteins arrange themselves into two rings around this central area. Microscope image shows an immunological synapse.
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This, however, could not be proved for the other molecules. Dustin to simulate the formation of synapses using computer models. In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly.
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Computer simulation of an immunological synapse with its characteristic ring-shaped structure. The antigen receptors are small and are repelled by the large adhesion molecules.
They organise themselves in small clusters which are transported by actin in the direction of the centre of the synapse. Frank Stieler and Dr. The combined business will operate under the brand KraussMaffei. This new plant will help boost its polypropylene capacity by more than 25 per cent to 2.
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