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Therefore previously non annotated regions can be discovered if such regions fall within less well a priory investigated regions. Due to the arbitrary length of depleted regions, under sampling and insertion biases a Hidden Markov Model is employed to classify regions as essential and non essential. Congenital coarctation of the Aorta CoA is an abnormal narrowing of the aorta from birth. It is usually associated with high blood pressure and the risk of developing further vascular diseases. Patients suffering from CoA have reduced live expectancy, highly depending on the degree of coarctation.

An intervention is usually performed when a pressure drop or gradient in excess of 20mmHg exists along the coarctation. The pressure drop is measured with an expensive, invasive catheterisation method.

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An alternative to measuring the pressure drop with a catheter is to use computational fluid dynamics CFD to compute the flow and pressure inside of an aorta. This technique is relatively new and first has to be validated against measured data before being put into practice. The report aims at obtaining such a validation, by comparing measured data prior to the intervention and after the intervention with simulated data in ANSYS fluent, a CFD solver.

Setting up of an ANSYS fluent simulation requires several steps which are outlined in this report and follows the following rough guideline.

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Segmentation extracts the 3D geometry of the aorta as a surface. The surface is loaded into fluent after further processing. Flow information from MRI is extracted to be used as conditions in the simulation. The CFD solver is set up and the results are analysed and compared with the measured values.

CFD simulations have the great potential to accurately predict the flow at every point within the aorta, with future applications in stent placement optimisation and aiding in choosing the appropriate type of stent.

March Close Project Photoacoustic sensing of lipids. Photoacoustic imaging uses an amplitude modulated signal to drive a laser in the near infrared range. Due to the absorption of light in the medium, the sample is heated. The alteration in heating causes the tissue to contract and expand and different rates, building up thermal stress. The thermal stress results in a pressure wave that can be detected with a transducer.

The aim of this report is find such a signal from biological tissues particularly fat and a fibre coating material. January Close Project A model of thermotherapy treatment for bladder cancer.

In this work, we investigate chemo- thermotherapy, a recently clinically-approved post-surgery treatment of non muscle invasive urothelial bladder carcinoma. We developed a mathematical model and numerically sim- ulated the physical processes related to this treatment.

The model parameters corre- spond to the data provided by the thermotherapy device manufacturer. We base our computational domain on a CT image of a human bladder. Our nu- merical simulations can be applied to further research on the effects of chemo- thermotherapy on bladder and surrounding tissues and for treatment person- alization in order to maximize the effect of the therapy while avoiding burning of the bladder. Alzheimer's disease is a form of dementia affecting mainly the elderly. Symptoms are loss of short term memory in the early stages up to shut down of basic bodily functions leading to death in the final stages.

There is currently no treatment for the prevention or delay of AD,with medication manly focusing on suppressing AD symptoms.

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